{"header":{"numFound":51834831,"maxScore":1.0,"queryTime":907,"page":1,"pageSize":10},"results":[{"authors":[{"id":null,"fullName":"Nubiola, J. (Jaime)","name":"J.","surname":"Nubiola","rank":1,"pid":null}],"openAccessColor":null,"publiclyFunded":null,"eoscIfGuidelines":null,"type":"other","language":{"code":"spa","label":"Spanish; Castilian"},"countries":null,"subjects":[{"subject":{"scheme":"keyword","value":"Liberal education"},"provenance":null},{"subject":{"scheme":"keyword","value":"Educación liberal"},"provenance":null},{"subject":{"scheme":"keyword","value":"Materias Investigacion::Arte y Humanidades::Filosofía"},"provenance":null},{"subject":{"scheme":"FOS","value":"05 social sciences"},"provenance":null},{"subject":{"scheme":"keyword","value":"John Henry Newman"},"provenance":null},{"subject":{"scheme":"keyword","value":"Humanismo cristiano"},"provenance":null},{"subject":{"scheme":"keyword","value":"Christian humanism"},"provenance":null},{"subject":{"scheme":"FOS","value":"0503 education"},"provenance":null}],"mainTitle":"Shrimpton, P., The ‘Making of Men’. The Idea and reality of Newman’s university in Oxford and Dublin [Reseña]","subTitle":null,"descriptions":["Reseña de la obra de Shrimpton, Paul, The ‘Making of Men’. The Idea and reality of Newman’s university in Oxford and Dublin, Gracewing, Leominster, UK 2014, 587 pp."],"publicationDate":"2025-01-01","publisher":"Servicio de Publicaciones de la Universidad de Navarra","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::04c8b2fe24019c353d719329f81ce388","originalIds":["oai:navarra.escire.net:10171/39916","50|00064aabbda9::04c8b2fe24019c353d719329f81ce388"],"pids":[{"scheme":"handle","value":"10171/39916"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.193092E-9,"popularity":2.292613E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/39916"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/39916"],"publicationDate":"2025-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"otherTitles":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Uribarrena, M. (Maialen)","name":"M.","surname":"Uribarrena","rank":1,"pid":null},{"id":null,"fullName":"Rovira-Cal, E. (Eric)","name":"E.","surname":"Rovira-Cal","rank":2,"pid":null},{"id":null,"fullName":"Urbina, L. (Leire)","name":"L.","surname":"Urbina","rank":3,"pid":null},{"id":null,"fullName":"Suárez, M.J. (María José)","name":"M. J.","surname":"Suárez","rank":4,"pid":null},{"id":null,"fullName":"Aymerich-Soler, E. (Enrique)","name":"E.","surname":"Aymerich-Soler","rank":5,"pid":null},{"id":null,"fullName":"Guerrero, P. (Pedro)","name":"P.","surname":"Guerrero","rank":6,"pid":null},{"id":null,"fullName":"De-la-Caba, K. (Koro)","name":"K.","surname":"De-La-Caba","rank":7,"pid":null},{"id":null,"fullName":"Etxabide, A. (Alaitz)","name":"A.","surname":"Etxabide","rank":8,"pid":null}],"openAccessColor":null,"publiclyFunded":null,"eoscIfGuidelines":null,"type":"other","language":{"code":"eng","label":"English"},"countries":null,"subjects":[{"subject":{"scheme":"FOS","value":"0404 agricultural biotechnology"},"provenance":null},{"subject":{"scheme":"keyword","value":"Cheese protein."},"provenance":null},{"subject":{"scheme":"keyword","value":"Food packaging waste reduction"},"provenance":null},{"subject":{"scheme":"keyword","value":"Compression moulding."},"provenance":null},{"subject":{"scheme":"keyword","value":"Industrial composting."},"provenance":null},{"subject":{"scheme":"FOS","value":"04 agricultural and veterinary sciences"},"provenance":null},{"subject":{"scheme":"keyword","value":"Food waste valorisation"},"provenance":null}],"mainTitle":"Valorization of cheese whey: closing the loop from protein extraction to whey protein film composting.","subTitle":null,"descriptions":["Whey protein extracted from cheese-making by-products was analysed as a potential alternative for both food waste valorisation and food packaging waste reduction. Whey protein was ultrafiltered from local cheese whey and used for film manufacture via compression moulding. The physicochemical characterization of the extracted protein showed that the purity of the extracted protein was 91.6% wt. FTIR and XRD analyses, as well as SEM images, revealed the presence of lactose in the extracted protein. The solubility of the films made in water indicated that whey protein films would be suitable for packaging fatty foods, e.g. cheese, thus following the circular economy strategy. Furthermore, since the biodegradability of the f ilms was higher than 70% after 48 h under composting conditions, it can be concluded that whey protein f ilms are rapidly compostable in any industrial composting facility, highlighting the more sustainable character of these films. Finally, the environmental assessment confirmed that the film manufacturing process was the stage contributing the most to the environmental impact and, thus, this step should be optimised to reduce the environmental footprint of the films developed."],"publicationDate":"2024-04-01","publisher":"Royal Society of Chemistry","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::08d276cf59330ad2189befab57effe18","originalIds":["oai:navarra.escire.net:10171/69332","50|00064aabbda9::08d276cf59330ad2189befab57effe18"],"pids":[{"scheme":"handle","value":"10171/69332"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.193092E-9,"popularity":1.9807764E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/69332"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/69332"],"publicationDate":"2024-04-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"otherTitles":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Oteiza-Rius, I. (Inés)","name":"I.","surname":"Oteiza-Rius","rank":1,"pid":null},{"id":null,"fullName":"Estenaga, Á. (Ángela)","name":"Á","surname":"Estenaga","rank":2,"pid":null},{"id":null,"fullName":"Antoñanzas, J. (Javier)","name":"J.","surname":"Antoñanzas","rank":3,"pid":null},{"id":null,"fullName":"Morelló-Vicente, A. (Ana)","name":"A.","surname":"Morelló-Vicente","rank":4,"pid":null},{"id":null,"fullName":"Laíño-Piñeiro, M. (M.)","name":"M.","surname":"Laíño-Piñeiro","rank":5,"pid":null},{"id":null,"fullName":"Mitxelena, J. (Josune)","name":"J.","surname":"Mitxelena","rank":6,"pid":null},{"id":null,"fullName":"Aguado, L. (Leyre)","name":"L.","surname":"Aguado","rank":7,"pid":null}],"openAccessColor":null,"publiclyFunded":null,"eoscIfGuidelines":null,"type":"other","language":{"code":"eng","label":"English"},"countries":null,"subjects":[{"subject":{"scheme":"keyword","value":"Materias Investigacion::Ciencias de la Salud"},"provenance":null},{"subject":{"scheme":"FOS","value":"03 medical and health sciences"},"provenance":null},{"subject":{"scheme":"FOS","value":"0302 clinical medicine"},"provenance":null},{"subject":{"scheme":"keyword","value":"Tumor necrosis factor (TNF)-α inhibitor"},"provenance":null},{"subject":{"scheme":"keyword","value":"Materias Investigacion::Ciencias de la Salud::Dermatología"},"provenance":null},{"subject":{"scheme":"keyword","value":"Adalimumab"},"provenance":null},{"subject":{"scheme":"keyword","value":"Covid 19 vaccination"},"provenance":null}],"mainTitle":"Generalized pustulosis following Covid 19 vaccination in a patient in treatment with adalimumab","subTitle":null,"descriptions":["Dear Editors, Adalimumab is a tumor necrosis factor (TNF)-α inhibitor commonly used for multiple autoimmune diseases. Paradoxical cutaneous reactions under anti-TNF-α drugs have been described in the literature, predominantly linked to adalimumab.1 Although this adverse effect is widely known, mechanisms underlying its induction, as well as possible risk factors, are still unknown. Here we report a case of papulopustular psoriasis induced by a second dose of Covid vaccine in a patient treated with adalimumab. The patient was a 52-year-old woman with history of HLA B27(–) spondylarthritis. No personal or family history of psoriasis was reported. During the previous 9 months she had been in treatment with adalimumab (40 mg) subcutaneously every 2 weeks. No other treatment was initiated during this period. However, she had received the second Covid vaccine the previous week (1st dose: Janssen, 2nd dose: Moderna). The patient presented with an abruptly developed generalized papulopustular reaction that had initiated as a palmoplantar pustulosis (Figure 1). A biopsy was performed and revealed generalized pustulosis (Figure 2). Adalimumab was discontinued and daily topical application of clobetasol propionate 0.05% plus urea 20% resulted in progressive improvement of the lesions. However, although clinical improvement was noted after the use of topical corticosteroids, the patient did not present with complete remission of the lesions."],"publicationDate":"2024-01-01","publisher":"Wiley","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::0d8fe39b30ab14dc24ebbe1e9d7ab820","originalIds":["oai:navarra.escire.net:10171/69176","50|00064aabbda9::0d8fe39b30ab14dc24ebbe1e9d7ab820"],"pids":[{"scheme":"handle","value":"10171/69176"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.193092E-9,"popularity":1.9807764E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":[{"code":"covid-19","label":"Corona Virus Disease","provenance":null}],"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/69176"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/69176"],"publicationDate":"2024-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"otherTitles":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Becerril, S. (Sara)","name":"S.","surname":"Becerril","rank":1,"pid":null},{"id":null,"fullName":"Álvarez-Cienfuegos, J. (Javier)","name":"J.","surname":"Álvarez-Cienfuegos","rank":2,"pid":null},{"id":null,"fullName":"Rodriguez, A. (Amaia)","name":"A.","surname":"Rodriguez","rank":3,"pid":null},{"id":null,"fullName":"Catalan, V. (Victoria)","name":"V.","surname":"Catalan","rank":4,"pid":null},{"id":null,"fullName":"Ramirez, B. (Beatriz)","name":"B.","surname":"Ramirez","rank":5,"pid":null},{"id":null,"fullName":"Valenti, V. (Víctor)","name":"V.","surname":"Valenti","rank":6,"pid":null},{"id":null,"fullName":"Moncada, R. (Rafael)","name":"R.","surname":"Moncada","rank":7,"pid":null},{"id":null,"fullName":"Unamuno, X. (Xabier)","name":"X.","surname":"Unamuno","rank":8,"pid":null},{"id":null,"fullName":"Gomez-Ambrosi, J. (Javier)","name":"J.","surname":"Gomez-Ambrosi","rank":9,"pid":null},{"id":null,"fullName":"Frühbeck, G. (Gema)","name":"G.","surname":"Frühbeck","rank":10,"pid":null}],"openAccessColor":null,"publiclyFunded":null,"eoscIfGuidelines":null,"type":"other","language":{"code":"eng","label":"English"},"countries":null,"subjects":[{"subject":{"scheme":"keyword","value":"Glucose metabolism"},"provenance":null},{"subject":{"scheme":"keyword","value":"Diet-induced obesity"},"provenance":null},{"subject":{"scheme":"keyword","value":"Single anastomosis duodeno-ileal bypass"},"provenance":null},{"subject":{"scheme":"keyword","value":"Sleeve gastrectomy"},"provenance":null}],"mainTitle":"Single anastomosis duodeno-ileal bypass with sleeve gastrectomy generates sustained improvement of glycemic control compared with sleeve gastrectomy in the diet-induced obese rat model","subTitle":null,"descriptions":["Bariatric surgery has become a recognized and effective procedure for treating obesity and type 2 diabetes (T2D). Our objective was to directly compare the caloric intake-independent effects of sleeve gastrectomy (SG) and single anastomosis duodenoileal bypass with SG (SADI-S) on glucose tolerance in rats with diet-induced obesity (DIO) and to elucidate the differences between bariatric surgery and caloric restriction.A total of 120 adult male Wistar rats with DIO and insulin resistance were randomly assigned to surgical (sham operation, SG, and SADI-S) and dietary (pair-feeding the amount of food eaten by animals undergoing the SG or SADI-S surgeries) interventions. Body weight and food intake were weekly monitored, and 6 weeks after interventions, fasting plasma glucose, oral glucose and insulin tolerance tests, plasma insulin, adiponectin, GIP, GLP-1, and ghrelin levels were determined.The body weight of SADI-S rats was significantly (p < 0.001) lower as compared to the sham-operated, SG, and pair-fed groups. Furthermore, SADI-S rats exhibited decreased whole body fat mass (p < 0.001), lower food efficiency rates (p < 0.001), and increased insulin sensitivity, as well as improved glucose and lipid metabolism compared to that of the SG and pair-fed rats.SADI-S was more effective than SG, or caloric restriction, in improving glycemic control and metabolic profile, with a higher remission of insulin resistance as well as long-term weight loss."],"publicationDate":"2024-01-01","publisher":"Springer","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::11a769e3b46919298e0f5aa9a7418d34","originalIds":["50|00064aabbda9::11a769e3b46919298e0f5aa9a7418d34","oai:navarra.escire.net:10171/69351"],"pids":[{"scheme":"handle","value":"10171/69351"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.193092E-9,"popularity":1.9807764E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/69351"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/69351"],"publicationDate":"2024-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"otherTitles":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Castelló, M. (Mercedes)","name":"M.","surname":"Castelló","rank":1,"pid":null}],"openAccessColor":null,"publiclyFunded":null,"eoscIfGuidelines":null,"type":"other","language":{"code":"spa","label":"Spanish; Castilian"},"countries":null,"subjects":[{"subject":{"scheme":"keyword","value":"Universidad Complutense de Madrid"},"provenance":null},{"subject":{"scheme":"keyword","value":"Cadáveres"},"provenance":null},{"subject":{"scheme":"keyword","value":"Facultad de Medicina"},"provenance":null},{"subject":{"scheme":"keyword","value":"Reputación"},"provenance":null},{"subject":{"scheme":"keyword","value":"Crisis y recuperación"},"provenance":null}],"mainTitle":"El sótano de los horrores. Crisis y recuperación en la Universidad Complutense de Madrid","subTitle":null,"descriptions":["La quinta temporada de “The Walking Dead” se estrenó en España en octubre de 2014. Cuando terminó, los estudiantes de medicina de la Universidad Complutense de Madrid descubrieron con estupefacción que también ellos habían estado caminando entre cadáveres ese curso. A pocos metros de los laboratorios de Anatomía, más de 500 cuerpos se amontonaban indecentemente."],"publicationDate":"2024-01-01","publisher":null,"embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::12ee82279a6d09a302f3c5c7a66b720b","originalIds":["50|00064aabbda9::12ee82279a6d09a302f3c5c7a66b720b","oai:navarra.escire.net:10171/69147"],"pids":[{"scheme":"handle","value":"10171/69147"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.193092E-9,"popularity":1.9807764E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/69147"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/69147"],"publicationDate":"2024-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"otherTitles":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Durá-Travé, T. (Teodoro)","name":"T.","surname":"Durá-Travé","rank":1,"pid":null},{"id":null,"fullName":"Gallinas-Victoriano, F. (Fidel)","name":"F.","surname":"Gallinas-Victoriano","rank":2,"pid":null}],"openAccessColor":null,"publiclyFunded":null,"eoscIfGuidelines":null,"type":"other","language":{"code":"eng","label":"English"},"countries":null,"subjects":[{"subject":{"scheme":"keyword","value":"Dental caries"},"provenance":null},{"subject":{"scheme":"keyword","value":"Antimicrobial proteins"},"provenance":null},{"subject":{"scheme":"keyword","value":"Children"},"provenance":null},{"subject":{"scheme":"keyword","value":"Enamel defects"},"provenance":null},{"subject":{"scheme":"keyword","value":"Salivary flow Vitamin D deficiency"},"provenance":null}],"mainTitle":"Dental caries in children and vitamin D deficiency: a narrative review","subTitle":null,"descriptions":["Dental caries represents one of the most prevalent health problems in childhood. Numerous studies have assessed that vitamin D deficiency is highly related to dental caries in primary and permanent teeth in children. The aim of this study is to elaborate a narrative review about proposed mechanisms by which vitamin D deficiency interacts with dental caries process in children. Vitamin D deficiency during pregnancy may cause intrauterine enamel defects, and through childhood is accompanied by insufficient activity of antibacterial peptides, decreased saliva secretion, and a low level of calcium in saliva. Conclusion: In conclusion, vitamin D deficiency would increase the risk of caries in the primary and/or permanent dentition. Relationship between vitamin D deficiency and dental caries is evident enough for vitamin D deficiency to be considered as a risk factor for dental caries in children. Optimal levels of vitamin D throughout pregnancy and childhood may be considered an additional preventive measure for dental caries in the primary and permanent dentition."],"publicationDate":"2024-01-01","publisher":"Springer","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::13e07a8d349b69acbf8835e124ff8187","originalIds":["oai:navarra.escire.net:10171/69350","50|00064aabbda9::13e07a8d349b69acbf8835e124ff8187"],"pids":[{"scheme":"handle","value":"10171/69350"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.193092E-9,"popularity":1.9807764E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/69350"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/69350"],"publicationDate":"2024-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"otherTitles":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Sánchez-Lorenzo, M. L. (María Luisa)","name":"M. L.","surname":"Sánchez-Lorenzo","rank":1,"pid":null},{"id":null,"fullName":"Bachiller, A. (Alejandra)","name":"A.","surname":"Bachiller","rank":2,"pid":null},{"id":null,"fullName":"Gea, C. (Claudia)","name":"C.","surname":"Gea","rank":3,"pid":null},{"id":null,"fullName":"Espinos, J. (Jaime)","name":"J.","surname":"Espinos","rank":4,"pid":null}],"openAccessColor":null,"publiclyFunded":null,"eoscIfGuidelines":null,"type":"other","language":{"code":"eng","label":"English"},"countries":null,"subjects":[{"subject":{"scheme":"keyword","value":"HER2 positive"},"provenance":null},{"subject":{"scheme":"FOS","value":"03 medical and health sciences"},"provenance":null},{"subject":{"scheme":"keyword","value":"Anti-HER2 therapies"},"provenance":null},{"subject":{"scheme":"FOS","value":"0302 clinical medicine"},"provenance":null},{"subject":{"scheme":"keyword","value":"Metastatic breast cancer"},"provenance":null},{"subject":{"scheme":"keyword","value":"Trial"},"provenance":null}],"mainTitle":"Current management and future perspectives in metastatic HER2-Positive breast cancer","subTitle":null,"descriptions":["Objective: Metastatic HER2-positive breast cancer remains a significant clinical challenge with a poor prognosis. The introduction of anti-HER2 therapies has significantly improved survival in early and advanced stages. However, patients with metastatic HER2-positive breast cancer eventually experience progression due to de novo or acquired resistance. This review article comprehensively analyzes the current management of metastatic HER2-positive breast cancer, addressing the complexities in determining the optimal HER2-targeted therapy sequence. Data Sources: Discussion of selected peer-reviewed articles and expert opinion. Conclusions: We explore the actual standard of care and the emerging therapeutic options that hold promise for further improving patient care and survival in this aggressive breast cancer subtype. This article highlights vital toxicities linked to anti-HER2 therapies, emphasizing their recognition across treatments as interstitial lung disease, diarrhea, or left ventricular dysfunction. Implications for Nursing Practices: Oncology nurses have a key role to play in detecting potential adverse effects of anti-HER2 therapies. The development of new drugs, as antibody drug conjugates, with a distinct toxicity profile makes it necessary for us to be updated on the management of these new toxicities."],"publicationDate":"2024-01-01","publisher":"Elsevier BV","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::1628e56e1027a3d3c83a52fd0a57dee0","originalIds":["oai:navarra.escire.net:10171/69253","50|00064aabbda9::1628e56e1027a3d3c83a52fd0a57dee0"],"pids":[{"scheme":"handle","value":"10171/69253"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.193092E-9,"popularity":1.9807764E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":[{"code":"cancer-research","label":"Cancer Research","provenance":null}],"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/69253"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/69253"],"publicationDate":"2024-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"otherTitles":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Ausejo-Mauleón, I. (Iker)","name":"I.","surname":"Ausejo-Mauleón","rank":1,"pid":null}],"openAccessColor":null,"publiclyFunded":null,"eoscIfGuidelines":null,"type":"other","language":{"code":"eng","label":"English"},"countries":null,"subjects":[{"subject":{"scheme":"keyword","value":"Diffuse intrinsic pontine glioma"},"provenance":null},{"subject":{"scheme":"keyword","value":"Pediatric brain tumors"},"provenance":null},{"subject":{"scheme":"FOS","value":"03 medical and health sciences"},"provenance":null},{"subject":{"scheme":"FOS","value":"0302 clinical medicine"},"provenance":null},{"subject":{"scheme":"keyword","value":"Diffuse Midline Glioma"},"provenance":null},{"subject":{"scheme":"keyword","value":"TIM-3 blockade"},"provenance":null},{"subject":{"scheme":"keyword","value":"Immunotherapy"},"provenance":null},{"subject":{"scheme":"keyword","value":"Brain tumors"},"provenance":null},{"subject":{"scheme":"keyword","value":"Materias Investigacion::Ciencias de la Salud::Oncología"},"provenance":null}],"mainTitle":"TIM-3 blockade as a therapeutic approach for diffuse intrinsic pontine glioma","subTitle":null,"descriptions":["Diffuse intrinsic pontine gliomas (DIPG) is an aggressive brain tumor and the leading cause of pediatric death caused by cancer. Despite great strides in understanding this disease, prognosis is dismal, with over 90% of patients dying within two years of diagnosis and a median overall survival time of 9-12 months. These grim statistics underscore that DIPG is an unmet clinical need. In this doctoral thesis, I have evaluated the local administration of an anti-TIM-3 antibody in anti-TIM-3 antibody in syngeneic orthotopic models of DIPG as a therapeutic approach for this disease. Our work uncovered, through in silico studies in patient datasets (whole RNAseq and scRNAseq) and samples (by multiplex IF) that TIM-3 was robustly expressed in tumor cells and tumor microenvironment, mainly in microglia and macrophages, suggesting this molecule as a potential therapeutic target in DIPGs. Mechanistic studies showed that TIM-3 provided intrinsic survival cues to the tumor cell while modulating the tumor microenvironment when expressed in the myeloid compartment. In vivo studies showed that TIM-3 blockade significantly increased the overall survival of DIPG immunocompetent orthotopic models, led to long-term survivors, and showed immune memory. TIM-3 inhibition resulted in an increase in the number and proliferative state of microglia, NK cells, and CD8+ T cells and higher levels of IFN, GrzB, and TNF&945; corresponding to NK and T-cell activate phenotypes. Interestingly, there was a decrease in the Treg population, which caused an increase in the pro-inflammatory CD8/Treg ratio. Chemokine studies demonstrated an augmentation of CCL5, CCL2 chemotactic chemokines, and CXCL10, IL-1;, and IFN- pro-inflammatory cytokines in the tumor microenvironment of treated mice. Additionally, DCs, CD4+, and CD8+ T cells were increased in treated draining lymph nodes and of functional significance, expressed higher amounts of pro-inflammatory cytokines than in control mice. Interestingly, the depletion of NK cells, CD4+, and CD8+ T cells immune populations did not completely abrogate the treatment efficacy. However, microglia and macrophages depletion with an anti-CSF1R resulted in a total loss due to a loss of microglia and CD8 T cells pro-inflammatory populations, chemokines, and cytokines indicating a critical role of these populations in the therapeutic effect of TIM-3 blockade. This study provides a new and previously unstudied view of DIPG treatment. TIM-3 blockade emerges as an exciting alternative to classical immune checkpoints, such as PD-1, that did not obtain the desired results in DIPG clinical trials. Moreover, the lack of other effective therapies for these devastating pediatric brain tumors makes these pre-clinical results especially promising and offers strong support for initiating a clinical trial with an anti-TIM-3 antibody for the treatment of DIPG."],"publicationDate":"2024-02-13","publisher":"Universidad de Navarra","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Alonso-Roldán, M.M. (Marta María)","Pastor, F. (Fernando)","Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::17a450b7e698cc2348b14d044bdafc76","originalIds":["50|00064aabbda9::17a450b7e698cc2348b14d044bdafc76","oai:navarra.escire.net:10171/69095"],"pids":[{"scheme":"handle","value":"10171/69095"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.193092E-9,"popularity":1.9807764E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":[{"code":"cancer-research","label":"Cancer Research","provenance":null}],"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/69095"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/69095"],"publicationDate":"2024-02-13","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"otherTitles":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"León-Parodi, J. (Joaquín)","name":"J.","surname":"León-Parodi","rank":1,"pid":null}],"openAccessColor":null,"publiclyFunded":null,"eoscIfGuidelines":null,"type":"other","language":{"code":"spa","label":"Spanish; Castilian"},"countries":null,"subjects":[{"subject":{"scheme":"FOS","value":"05 social sciences"},"provenance":null},{"subject":{"scheme":"keyword","value":"Materias Investigacion::Educación"},"provenance":null},{"subject":{"scheme":"keyword","value":"Antropología trascendental"},"provenance":null},{"subject":{"scheme":"keyword","value":"Persona"},"provenance":null},{"subject":{"scheme":"keyword","value":"Filosofía de la educación"},"provenance":null},{"subject":{"scheme":"FOS","value":"0503 education"},"provenance":null},{"subject":{"scheme":"keyword","value":"Leonardo Polo"},"provenance":null}],"mainTitle":"La Educación centrada en la persona. Fundamentación antropológica de la educación desde la filosofía de Leonardo Polo","subTitle":null,"descriptions":["--"],"publicationDate":"2024-01-18","publisher":"Universidad de Navarra","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Sellés-Dauder, J.F. (Juan Fernando)","Mercado, J.A. (Juan Andrés)","Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::183ea0dcc8b1c9cb297567cf4454dd1e","originalIds":["oai:navarra.escire.net:10171/68416","50|00064aabbda9::183ea0dcc8b1c9cb297567cf4454dd1e"],"pids":[{"scheme":"handle","value":"10171/68416"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.193092E-9,"popularity":1.9807764E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/68416"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/68416"],"publicationDate":"2024-01-18","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"otherTitles":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Fantova-Sarasa, J. (Jorge)","name":"J.","surname":"Fantova-Sarasa","rank":1,"pid":null},{"id":null,"fullName":"Rodríguez-González, A. (Ainara)","name":"A.","surname":"Rodríguez-González","rank":2,"pid":null},{"id":null,"fullName":"Del-Hoyo, J. (Jesús)","name":"J.","surname":"Del-Hoyo","rank":3,"pid":null},{"id":null,"fullName":"Garcia-Mandayo, G. (Gemma)","name":"G.","surname":"Garcia-Mandayo","rank":4,"pid":null},{"id":null,"fullName":"Olaizola-Izquierdo, S.M. (Santiago Miguel)","name":"S. M.","surname":"Olaizola-Izquierdo","rank":5,"pid":null}],"openAccessColor":null,"publiclyFunded":null,"eoscIfGuidelines":null,"type":"other","language":{"code":"eng","label":"English"},"countries":null,"subjects":[{"subject":{"scheme":"keyword","value":"Bessel beams."},"provenance":null},{"subject":{"scheme":"keyword","value":"Ultrafast laser writing."},"provenance":null},{"subject":{"scheme":"keyword","value":"Diffraction."},"provenance":null},{"subject":{"scheme":"keyword","value":"Wave-guides."},"provenance":null},{"subject":{"scheme":"FOS","value":"01 natural sciences"},"provenance":null},{"subject":{"scheme":"keyword","value":"Bragg."},"provenance":null},{"subject":{"scheme":"keyword","value":"Fused-silica."},"provenance":null},{"subject":{"scheme":"keyword","value":"Heat accumulation."},"provenance":null},{"subject":{"scheme":"keyword","value":"Volume gratings."},"provenance":null},{"subject":{"scheme":"FOS","value":"0103 physical sciences"},"provenance":null},{"subject":{"scheme":"keyword","value":"Área Ingeniería Eléctrica, Electrónica y Automática"},"provenance":null},{"subject":{"scheme":"keyword","value":"Laser."},"provenance":null},{"subject":{"scheme":"keyword","value":"Nonlinear optical materials."},"provenance":null},{"subject":{"scheme":"keyword","value":"Volume phase gratings."},"provenance":null}],"mainTitle":"Bessel beams as a versatile tool to generate embedded devices in optical glasses","subTitle":null,"descriptions":["Beam shaping offers many opportunities to both streamline and accelerate laser fabrication processes, closing the gap between lab research and large-scale manufacturing. In the field of embedded devices, a Bessel beam configuration allows for large volume engraving of transparent materials in a single laser pass. In this work, we take advantage of femtosecond Bessel beams with a length of 340 mu m and a diameter of 1 mu m to generate diffractive elements within three distinct optical glasses. This strategy represents a chemical-free and cost-effective alternative to the conventional manufacturing of holographic elements based on photoresist micro-patterning. Despite the different nonlinear effects taking place in each material, we report the successful fabrication of diffraction gratings operating at either normal or Bragg incidence, with efficiencies in the first combined order of up to 70%. Our experimental results show the potential of Bessel beams as a tool to produce buried light devices in a wide variety of glass materials."],"publicationDate":"2024-01-01","publisher":null,"embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::18b705f7b82c02d3156551062df1a712","originalIds":["50|00064aabbda9::18b705f7b82c02d3156551062df1a712","oai:navarra.escire.net:10171/69339"],"pids":[{"scheme":"handle","value":"10171/69339"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.193092E-9,"popularity":1.9807764E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/69339"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/69339"],"publicationDate":"2024-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"otherTitles":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null}]}