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Therapeutic options for first-line acute attacks are intravenous administration of glucose and/or exogenous heme. The former treatment can aggravate hyponatremia by dilution and cause seizures; thus, the correction of hyponatremia must be carried out with extreme caution. This review summarizes recommendations for the management of hyponatremia during acute episodes of porphyria. Hyponatremia should be corrected slowly and seizures treated with medications in order to not exacerbate motor and sensory axonal neuropathy. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is considered a frequent cause of hyponatremia in acute porphyrias and must be identified as a symptom of an acute porphyria attack. Tolvaptan produces aquaresis and is considered a safe drug in porphyria. However, its use has only been reported in isolated cases during a porphyria attack. The convenience and usefulness of this drug in acute porphyria are discussed."],"publicationDate":"2020-01-01","publisher":"AME","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::02462316312f15cf24dbea9e943104a1","originalIds":["oai:navarra.escire.net:10171/66215","50|00064aabbda9::02462316312f15cf24dbea9e943104a1"],"pids":[{"scheme":"handle","value":"10171/66215"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.193092E-9,"popularity":1.1312192E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/66215"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/66215"],"publicationDate":"2020-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"otherTitles":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Arrosagaray-Auzqui, M. 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Aplicación práctica en el nivel C1 del MCER","subTitle":null,"descriptions":["La enseñanza de la pronunciación del inglés como lengua extranjera ha estado sujeta a grandes variaciones hasta considerarla finalmente como un componente más en la enseñanza de la lengua inglesa actualmente (Celce-Murcia, Brinton y Goodwin, 1996, 2010; Levis, 2005). La pronunciación ha pasado de ser considerada como una disciplina teórica (Seidlhofer, 2001; Setter, 2008) a alcanzar una mayoría de edad plena y adquirir un nuevo protagonismo didáctico: ¿To reemerge as a more flexible and more relevant language phenomenon, able to adapt to its context of use and to relate in both teaching and research to other linguistic areas¿ (Jenkins, 2004:120). Su inclusión en el currículo bajo el enfoque comunicativo predominante en la enseñanza del inglés como lengua extranjera (EFL) genera un gran reto aún sin resolver. La reducida experimentación e investigación existente en cómo orientar la enseñanza de la pronunciación con fines comunicativos traslada un reto muy grande al docente (Derwing y Munro, 2005), cuyo perfil adecuado exige conocimientos sobre fonética articulatoria, teorías de adquisición fonológica, y el manejo de técnicas y procedimientos de aula. En la práctica, actualmente se produce un rechazo y olvido de la fonética ante la poca claridad existente y la complejidad que conlleva su enseñanza (Derwing 2010; Levis y LeVelle, 2010). A su vez, la enseñanza de adultos constituye un contexto de aprendizaje específico dada su madurez cognitiva, sus conocimientos lingüísticos, su experiencia vital de aprendizaje, su disponibilidad de tiempo, y su posible resistencia a expresarse en el idioma, si creen no hacerlo correctamente (Lightbown y Spada, 2006). Nuestra investigación propone la aplicación de un programa pedagógico para orientar la enseñanza y el aprendizaje de la pronunciación de adultos hacia la mejora de su capacidad comunicativa promoviendo una triple interacción mediante la aplicación de las perspectivas comunicativa e integrativa en el uso de las TIC (Kern & Warschauer, 2000; Warschauer, 1996, 2000): (i) del alumno con el contenido, en una primera fase de familiarización, (ii) del alumno con el profesor, en una fase de comunicación estructurada, y (iii) de un alumno con otro-s, en una fase comunicativa libre, con dinámicas específicas establecidas para cada fase, que los alumnos del grupo experimental realizan mediante el uso de la tecnología seleccionada por el profesor, y combinando el trabajo del aula con el personal del alumno, y los del grupo de control siguiendo el libro de texto y material adicional fotocopiable de manera tradicional. Tras la intervención didáctica, los alumnos muestran un perfeccionamiento de su pronunciación en el reconocimiento y la producción de fonemas y algún rasgo prosódico analizado, como la acentuación de la palabras y la distribución del acento oracional (tonicity or nuclear stress). Asimismo, los alumnos muestran un afianzamiento sobre su protagonismo en el aprendizaje de la pronunciación, y una satisfacción generalizada con el programa ejercitado. A partir de las evidencias encontradas, se sugieren futuras líneas de investigación ampliando la escala de la muestra y la variedad de contenidos y actividades analizados para mantener la práctica viva en el futuro."],"publicationDate":"2020-03-11","publisher":null,"embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Breeze, R. (Ruth)","Sobrino, A. 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