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METHODS: Patients diagnosed with bone metastases secondary to breast, prostate or lung cancer were included in this multicentre, observational study. SREs are defined as pathologic fracture (vertebral and non-vertebral fracture), radiation to bone, spinal cord compression or surgery to bone. Health resource utilisation associated with these events (inpatient stays, outpatient, emergency room and home health visits, nursing home stays and procedures) were collected retrospectively for all SREs that occurred in the 97 days prior to enrolment and prospectively during follow-up. Unit costs were obtained from the 2010 eSalud healthcare costs database. RESULTS: A total of 93 Spanish patients with solid tumours were included (31 had breast cancer, 21 prostate cancer and 41 lung cancer), contributing a total of 143 SREs to this cost analysis. Inpatient stays (between 9.0 and 29.9 days of mean length of stay per inpatient stay by SRE type) and outpatient visits (between 1.7 and 6.4 mean visits per SRE type) were the most frequently reported types of health resources utilised. The mean cost per SRE was between <euro>2,377.79 (radiation to bone) and <euro>7,902.62 (spinal cord compression). 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El objeto de este artículo es revisar las posibilidades que esta tecnología ofrece para su incorporación como sistema de climatización de edificios, centrándose en la descripción y análisis del comportamiento del último prototipo realizado dentro de un proyecto de investigación. Para ello, se describen los criterios de diseño y los componentes necesarios para su montaje, aspectos en los que ha tenido especial importancia la reducción del puente térmico respecto a prototipos anteriores. Se explica la metodología experimental seguida, los ensayos realizados, y se analizan críticamente los resultados. Las conclusiones plantean mejoras y recomendaciones para implementar en futuros desarrollos."],"publicationDate":"2021-01-01","publisher":"Consejo Superior de Investigaciones Científicas","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::00241a01459ab0aca26e3032633b869b","originalIds":["50|00064aabbda9::00241a01459ab0aca26e3032633b869b","oai:navarra.escire.net:10171/63885"],"pids":[{"scheme":"handle","value":"10171/63885"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.3384854E-9,"popularity":1.4007638E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/63885"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/63885"],"publicationDate":"2021-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Reyes, R. 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Encapsulation efficiency was assessed and in vivo release kinetics of BMP-2 and MMP10 were examined over 14 days. Histological analyses were used to analyze bone formation after four and eight weeks. Combination with MMP10 (30 ng) significantly enhanced BMP-2 (600 ng)-mediated osteogenesis, as confirmed by the increase in percentage of bone fill (p < .05) at four weeks. Moreover, it also increased mineral apposition rate (p < .05), measured by double labeling with tetracycline and calceine. MMP10 accelerates bone repair by enhancing BMP-2- promoted bone healing and improving the mineralization rate. In conclusion combination of MMP10 and BMP-2 may become a promising strategy for repair and regeneration of bone defects."],"publicationDate":"2018-01-01","publisher":"Taylor & Francis","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::0024735bf4677313a8ba5aca234616fb","originalIds":["oai:navarra.escire.net:10171/64848","50|00064aabbda9::0024735bf4677313a8ba5aca234616fb"],"pids":[{"scheme":"handle","value":"10171/64848"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.3384854E-9,"popularity":9.41487E-10,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/64848"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/64848"],"publicationDate":"2018-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Zermeño-Flores, A.I. 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This audiovisual narrative depicts key problems of the present in a representation of the near future, enabling the identification of new socio-technological paradigms. We applied the method of Causal Layered Analysis (CLA), a prospective analytical tool used both for the study of diverse current phenomena and for the design of possible futures, which includes the levels of the litany, systemic causes, discourse/world vision, and myth/metaphor. The analysis showed that <em>Years and Years</em> offers a vision of a world in chaos, based on a global capitalist and technological project that threatens fundamental rights, and the existence of the human species. In the series, technologies are imbibed in all the fundamental systems of Western societies, pushing common people into obsolescence. Three narratives uphold the myth of the dominion of science and technology: the technological transcendence of human beings, the irrelevance of humans before technology, and the ubiquitous panopticon of digitized power. 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En definitiva, mediante la Reserva de la Biosfera Intercontinental del Mediterráneo se trata de situar el medio ambiente como un factor de dinamización de las relaciones transfronterizas entre Andalucía y el norte de Marruecos, factor sobre el que pivotará un conjunto de actuaciones dirigidas no sólo a la conservación de los ricos y valiosos ecosistemas que se encuentran en la zona, sino también a la dinamización de las economías locales sobre un modelo de desarrollo sostenible."],"publicationDate":"2012-01-01","publisher":"Servicio de Publicaciones de la Universidad de Navarra","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::0031eeb7cb5244d0900f4705c11569b1","originalIds":["oai:navarra.escire.net:10171/34897","50|00064aabbda9::0031eeb7cb5244d0900f4705c11569b1"],"pids":[{"scheme":"handle","value":"10171/34897"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.3384854E-9,"popularity":4.814403E-10,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/34897"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/34897"],"publicationDate":"2012-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"López-Grigera, L. 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This article studies the ludicrous aspects in the Quixote, following the rhetoric theories taught in the Spanish universities during the second half of the XVIth Century. Cervantes proves himself as a good connoisseur of the classical rhetoric treaties (Aristotle, Cicero) and even those of his time (Torres, Palmireno). 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Veremos que la correspondencia entre el deber de amistad y el deber de promover el Sumo Bien es una correspondencia muy particular que no se puede trasladar a casos como la relación que puede haber entre el deber de beneficiencia y el Sumo Bien. Es verdad que, al cumplir con el deber de beneficencia, los hombres promueven una cultura moral. Sin embargo, la unión en la que consiste la amistad no refleja solo la existencia de una cultura moral entre los hombres, sino la de una sociedad ética."],"publicationDate":"2020-01-01","publisher":"Sociedad de Estudios Kantianos en Lengua Española","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::0034c99f7a1567fc2d6ffc0611bffcaa","originalIds":["50|00064aabbda9::0034c99f7a1567fc2d6ffc0611bffcaa","oai:navarra.escire.net:10171/62322"],"pids":[{"scheme":"handle","value":"10171/62322"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.3384854E-9,"popularity":1.2226317E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/62322"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/62322"],"publicationDate":"2020-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Llamas-Martínez, J. 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Sin embargo, tanto los epígrafes del poema, como la interpretación de los versos, hacen pensar que están dedicados al fallecimiento de su hermano, Pedro Girón Enríquez de Ribera (1586-1633), que tras su casamiento con la II marquesa de Alcalá de la Alameda, pasó a ser marqués consorte de Alcalá. De este matrimonio nació Ana María Luisa Per Afán Enríquez de Ribera Portocarrero Girón y Cárdenas, III marquesa de Alcalá de la Alameda, y esposa de Antonio Juan Luis de la Cerda, VII duque de Medinaceli, personajes a los que Quevedo parece apelar en los poemas. Además de una mejor lectura de los versos, que inciden en la proximidad entre el poeta y el duque de Medinaceli, este cambio en la atribución de los personajes permite ofrecer una ordenación más cabal de los poemas de «Melpómene» y relacionar la muerte de Pedro Girón Enríquez de Ribera con la redacción de Los remedios de cualquiera fortuna."],"publicationDate":"2016-01-01","publisher":"Servicio de Publicaciones de la Universidad de Navarra","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::0036c48be9e6be1c085c11e8edf3a20c","originalIds":["oai:navarra.escire.net:10171/52226","50|00064aabbda9::0036c48be9e6be1c085c11e8edf3a20c"],"pids":[{"scheme":"handle","value":"10171/52226"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.3384854E-9,"popularity":7.37334E-10,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/52226"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/52226"],"publicationDate":"2016-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Rosina, A. 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Exploring opinions of International Baccalaureate teachers about their teaching practices and the role of the language at Middle Years (MYP) and Diploma (DP) level","subTitle":null,"descriptions":["Keywords: ​ group work, talented students, teachers beliefs, teachers perceptions, teaching practice, IB group work, IB teaching, International Baccalaureate, IB language teaching, assessment, group work assessment, group assessment, high achievers Resumen La pregunta principal que este estudio pretende contribuir a responder es: “¿Se utiliza de manera efectiva el trabajo en grupo en el Bachillerato Internacional (IB) en los programas MYP y DP para estudiantes sobresalientes?”, explorando las opiniones de docentes del IB sobre sus prácticas y el papel que juega el aspecto lingüístico. El trabajo en grupo es hoy en día una práctica consolidada para cualquier materia que se imparte en el Bachillerato Internacional (IB) en los Años Intermedios (MYP, de 11 a 16 años) y Diploma (DP, de 16 a 19 años) y es también una herramienta común del enfoque comunicativo para la enseñanza de idiomas. Sin embargo, estudios previos ( ​ Frykedal y Chiriac, 2011; Chiriac y Granström, 2012; Le, Janssen y Wubbels, 2018 ​ ) han indicado que tanto los profesores como los estudiantes tienen dificultades al trabajar con grupos. La mayoría de los obstáculos están relacionados no solo con la evaluación en general y la evaluación individual de estudiantes de alto rendimiento ( ​ Dijkstra, Latijnhouwers, Norbart y Tio, 2016 ​ ), sino también con experiencias negativas ( ​ Pauli, Mohiyeddini, Bray, Michie y Street, 2008; Peterson e Irving, 2008 ​ ). Esta tesis del MUP ( ​​ Máster en Profesorado de Educación secundaria obligatoria, Bachillerato, FP, enseñanza de idioma ​ ) describe las percepciones sobre las experiencias de 10 docentes del IB en MYP y DP de la escuela secundaria “International Community School” de Londres, entrevistados en mayo de 2019. Las preguntas les hicieron reflexionar sobre sus prácticas y compartir opiniones sobre el trabajo en grupo. El objetivo principal de este estudio fue explorar cómo los profesores gestionan los desafíos, especialmente aquellos relacionados con la diferenciación para estudiantes con alto rendimiento, con el aspecto lingüístico, la efectividad percibida y la imparcialidad de las evaluaciones grupales y la evaluación de pares ( ​ peer assessment ​ ). 3 Usando el método fenomenológico de la investigación cualitativa, este estudio informa que los participantes identificaron varios desafíos relacionados con la actividad grupal","The main question that this study is intended to contribute to answering is: “ Is group work effectively used in IB at MYP and DP level for outstanding students?” exploring opinions of IB teachers about their practices and the role of the language. Group work is nowadays a consolidated practice for any subject taught in the International Baccalaureate (IB) both at Middle Years (MYP, students aged 11 to 16) and Diploma (DP, students aged 16 to 19) level and also a common tool of the communicative approach for teaching languages. However previous studies (Frykedal & Chiriac, 2011; Chiriac & Granström, 2012; Le, Janssen & Wubbels, 2018) have indicated that both teachers and students encounters difficulties while working with groups. Most of the obstacles are connected with assessment and individual assessment of talented students (Dijkstra, Latijnhouwers, Norbart & Tio, 2016), but also with negative experiences and presumptions (Pauli, Mohiyeddini, Bray, Michie & Street, 2008; Peterson & Irving, 2008). So how teachers plan and react when they set group work for talented (also known as advanced learners or high achievers or gifted ) students? What are the beliefs and practices? What are the real outcomes? Is language playing an important role and how is it used? This Master of Secondary Teaching thesis describes perceptions and opinions of 10 IB MYP and DP teachers of International Community School of London, interviewed in May 2019. Questions asked them to reflect about their practices and beliefs and to share their opinions about group work . The main purpose of this study was to obtain not only increased knowledge of how IB teachers assess individual learning occurring in group work, but also explore how teachers manage the emerging challenges, especially those related to the differentiation for high achieving students, assessing individual effort in a group work, peer assessment and the role of the language. Using the phenomenological method of qualitative research, this study reports that the participants identified various challenges within the purpose of the group activity."],"publicationDate":"2018-01-01","publisher":null,"embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Breeze, R. 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Desde el nacimiento del primer bebé mediante fecundación in vitro en 1978, por medio del avance científico, han ido surgiendo otros procedimientos en materia reproductiva que, cada vez, consiguen mayores intervenciones en la generación de vida humana.Los avances y descubrimientos logrados en Genética a raíz de los resultados del Proyecto Genoma Humano (PGH), no solo han tenido impacto en la investigación científica por la información que ahora se conoce, sino que estos conocimientos, sumados al desarrollo de tecnologías reproductivas, permiten la realización de estudios que analizan genéticamente a los embriones preimplantatorios para que, a partir de los resultados obtenidos, se pueda determinar su continuidad de vida según los criterios que se persigan."],"publicationDate":"2019-06-01","publisher":null,"embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Díaz-de-Terán-Velasco, M.C. 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The risk of symptomatic RN associated with stereotactic radiosurgery (SRS) as part of the treatment of brain metastases (BMs) has been a subject of recent investigation. The activation of the signal transducer and activator of transcription 3 (STAT3) was shown in reactive astrocytes (RA) associated with BMs. Given that the pathophysiological mechanisms behind RN are not fully understood, we sought to investigate the role of STAT3 among other inflammatory markers in RN development. A mouse model of RN using clinical LINAC-based SRS was designed to induce brain necrosis with the administration of 50 Gy in a single fraction to the left hemisphere using a circular collimator of 5 mm diameter. Immunohis- tochemistry and multiplex staining for CD4, CD8, CD68, GFAP, and STAT3 were performed. For validation, eleven patients with BMs treated with SRS who developed symptomatic RN and required surgery were identified to perform staining for CD68, GFAP, and STAT3. In the mouse model, the RN and perinecrotic areas showed significantly higher staining for F4/80+ and GFAP+ cells, with a high infiltration of CD4 and CD8 T-lymphocytes, when compared to the non-irradiated cerebral hemisphere. A high number of GFAP+pSTAT3+ and F4/80+pSTAT3+ cells was found in the RN areas and the rest of the irradiated hemisphere. The analysis of human brain specimens showed that astrocytes and microglia were actively phosphorylating STAT3 in the areas of RN and gliosis. Phosphorylated STAT3 is highly expressed in the microglia and RA pertaining to the areas of brain RN. Targeting STAT3 via inhibition represents a promising strategy to ameliorate symptomatic RN in BM patients undergoing SRS."],"publicationDate":"2023-01-01","publisher":"MDPI AG","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::0050b506e44f6cce879f58cab137b114","originalIds":["50|00064aabbda9::0050b506e44f6cce879f58cab137b114","oai:navarra.escire.net:10171/69060"],"pids":[{"scheme":"handle","value":"10171/69060"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.3384854E-9,"popularity":1.8551145E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/69060"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/69060"],"publicationDate":"2023-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Ainciburu-Fernández, M. 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However, limited data are available from the Spanish population. Our aim was to describe the influence of place of residence and habitat size on food group intakes. Data were obtained from the ANIBES study. A 3-day dietary record provided information on food and beverage consumption. Data analysis compared gender, age, Nielsen geographic areas, and habitat population size (urban, semi-urban, and rural). Place of residence did not appear to be a determinant for specific food group consumption during childhood and adolescence, as only higher intakes of non-alcoholic beverages were observed among children aged 9 to 12 years living in the East, when compared to those from the Northwest of Spain (p < 0.05)."],"publicationDate":"2018-01-01","publisher":"MDPI AG","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::006d07d56c9e2c370fe41ac7cc349386","originalIds":["oai:navarra.escire.net:10171/65876","50|00064aabbda9::006d07d56c9e2c370fe41ac7cc349386"],"pids":[{"scheme":"handle","value":"10171/65876"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.3384854E-9,"popularity":9.41487E-10,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/65876"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/65876"],"publicationDate":"2018-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Muñoz, M.A. (Miguel Angel)","name":"M. 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This study aims to analyze whether depression may influence the control of blood pressure in hypertensive individuals at high cardiovascular risk. Methods: Cross-sectional study, embedded within the PREDIMED clinical trial, of 5954 hypertensive patients with high cardiovascular risk factor profiles. The relationship between blood pressure control and depression was analyzed. A multivariate analysis (logistic and log-linear regression), adjusting for potential confounders (socio-demographic factors, body mass index, lifestyle, diabetes, dyslipidemia, and antihypertensive treatment), was performed. Results: Depressive patients, with and without antidepressant treatment, had better blood pressure control (OR: 1.28, CI 95%: 1.06-1.55, and OR: 1.30, CI 95%: 1.03-1.65, respectively) than non-depressive ones. Regarding blood pressure levels, systolic blood pressure values (mmHg) were found to be lower in both treated and untreated depressive patients (Log coefficient Beta: −1.59, 95% CI: −0.50 to −2.69 and Log coefficient Beta: −3.49, 95% CI: −2.10 to −4.87, respectively). Conclusions: Among hypertensive patients at high cardiovascular risk, the control of blood pressure was better in those diagnosed with depression. 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Se originó en una denuncia (Nº 11.154) recibida en la Secretaría de la Comisión el 6 de mayo de 1993. Al presentar el caso ante la Corte, la Comisión invocó los artículos 50 y 51 de la Convención Americana sobre Derechos Humanos (en adelante \"la Convención\" o \"la Convención Americana\") y 26 y siguientes del Reglamento. La Comisión sometió este caso para que la Corte decidiera si hubo violación de los siguientes artículos de la Convención: 7 (Derecho a la Libertad Personal), 5 (Derecho a la Integridad Personal), 8 (Garantías Judiciales) y 25 (Protección Judicial), todos ellos en concordancia con el artículo 1.1 de la misma Convención, por la supuesta \"privación ilegal de la libertad, tortura, tratos crueles inhumanos y degradantes, violación a las garantías judiciales y doble enjuiciamiento con base en los mismos hechos, de María Elena Loayza Tamayo, en violación de la Convención\" y del artículo 51.2 de la Convención por haberse negado a \"dar cumplimiento a las recomendaciones formuladas por la Comisión\". 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Se pretende demostrar que lo que la universidad necesita es una internacionalización cultural que enriquezca la experiencia educativa y sea una variante frente a los modelos economicistas vigentes."],"publicationDate":"2008-01-01","publisher":"Servicio de Publicaciones de la Universidad de Navarra","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::009eda27b81315ae5e8886b110aa4078","originalIds":["oai:navarra.escire.net:10171/9135","50|00064aabbda9::009eda27b81315ae5e8886b110aa4078"],"pids":[{"scheme":"handle","value":"10171/9135"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.3384854E-9,"popularity":3.465094E-10,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/9135"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/9135"],"publicationDate":"2008-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Miguel-Vallés, J. 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Se examinan varias parcelas en que el fenómeno reviste especial gravedad. Se aspira a seleccionar los términos según el criterio de su claridad conceptual para sustentar el edificio gramatical sobre cimientos y estructuras sólidos. This article intends to interfere with the excessive terminological divergence produced in the teaching of the Spanish language at secondary levels. Different fields in which this phenomenon is especially serious are examined. The purpose is to select the terms according to the criterion of conceptual clarity in order to hold the grammatical building on solid foundations and structures."],"publicationDate":"1989-01-01","publisher":"Servicio Publicaciones Universidad de Navarra","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::009ede527e70a4dadd317b620f45b638","originalIds":["oai:navarra.escire.net:10171/4183","50|00064aabbda9::009ede527e70a4dadd317b620f45b638"],"pids":[{"scheme":"handle","value":"10171/4183"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.3384854E-9,"popularity":2.0319743E-10,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/4183"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/4183"],"publicationDate":"1989-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Izquierdo, C. 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La historia de la Teología es testigo de que desde las primeras controversias teológicas hasta nuestros días, la razón creyente ha seguido diversos caminos para lograr una más perfecta explicación del incomprensible misterio de Dios, y a la vez para defender la Fe ortodoxa."],"publicationDate":"1982-01-01","publisher":"Servicio de Publicaciones de la Universidad de Navarra","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::00a044dceccf36520c89d80e03454fb2","originalIds":["50|00064aabbda9::00a044dceccf36520c89d80e03454fb2","oai:navarra.escire.net:10171/10948"],"pids":[{"scheme":"handle","value":"10171/10948"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.3384854E-9,"popularity":1.9834684E-10,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/10948"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/10948"],"publicationDate":"1982-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Gallego, A. 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Research on virulence factors of B. ovis is necessary for deciphering the mechanisms that enable this facultative intracellular pathogen to establish persistent infections and for developing a species-specifc vaccine, a need in areas where the cross-protecting ovine smooth B. melitensis Rev1 vaccine is banned. Although several B. ovis virulence factors have been identifed, there is little information on its metabolic abilities and their role in virulence. Here, we report that deletion of pyruvate phosphate dikinase (PpdK, catalyzing the bidirectional conversion pyruvate ⇌ phosphoenolpyruvate) in B. ovis PA (virulent and CO2-dependent) impaired growth in vitro. In cell infection experiments, although showing an initial survival higher than that of the parental strain, this ppdK mutant was unable to multiply. Moreover, when inoculated at high doses in mice, it displayed an initial spleen colonization higher than that of the parental strain followed by a marked comparative decrease, an unusual pattern of attenuation in mice. A homologous mutant was also obtained in a B. ovis PA CO2-independent construct previously proposed for developing B. ovis vaccines to solve the problem that CO2-dependence represents for large scale production. This CO2-independent ppdK mutant reproduced the growth defect in vitro and the multiplication/clearance pattern in mouse spleens, and is thus an interesting vaccine candidate for the immunoprophylaxis of B. ovis ovine brucellosis."],"publicationDate":"2020-01-01","publisher":null,"embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::00a4bdaf642672c3ae992556cdc24834","originalIds":["50|00064aabbda9::00a4bdaf642672c3ae992556cdc24834","oai:navarra.escire.net:10171/66344"],"pids":[{"scheme":"handle","value":"10171/66344"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.3384854E-9,"popularity":1.2226317E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/66344"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/66344"],"publicationDate":"2020-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Vélez-Sainz, J. 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Se trata de los siguientes ejemplares: De octo partibus or[ati] onis lib. I de Constantino Lascaris (Venecia, Aldo Manucio, 1512), De causis nostrarum calamitatum et de morbis epidemicis cum pronosticis vsq[ue] ad annum 1608 de Giovanni De Vito (Nápoles, Jacobo Carlino, 1602), De concordia liberi arbitrij, & praedestinationis diuinae de Johannes Driedo (Lovaina, Riger Reseij, 1537), y el Libro della natura et virtù delle cose che nutriscono & delle cose non naturali de Johannes Michael Savonarola (Venecia, Domenico & Giovanni Battista Guerra, 1576). Analizamos caligráficamente los comentarios marginales que hizo Quevedo en este último libro y sostenemos que son anotaciones marginales autógrafas de la pluma del madrileño."],"publicationDate":"2017-01-01","publisher":"Servicio de Publicaciones de la Universidad de Navarra","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::00a647d69a87fdf9551756278ff23d85","originalIds":["oai:navarra.escire.net:10171/57395","50|00064aabbda9::00a647d69a87fdf9551756278ff23d85"],"pids":[{"scheme":"handle","value":"10171/57395"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.3384854E-9,"popularity":8.312618E-10,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/57395"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/57395"],"publicationDate":"2017-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Herrero, M. (Montserrat)","name":"M.","surname":"Herrero","rank":1,"pid":null}],"openAccessColor":null,"publiclyFunded":null,"eoscIfGuidelines":null,"type":"other","language":{"code":"spa","label":"Spanish; Castilian"},"countries":null,"subjects":[{"subject":{"scheme":"keyword","value":"Locke"},"provenance":null},{"subject":{"scheme":"keyword","value":"Biblical Interpretation"},"provenance":null},{"subject":{"scheme":"keyword","value":"Bible"},"provenance":null},{"subject":{"scheme":"keyword","value":"Interpretación bíblica"},"provenance":null},{"subject":{"scheme":"keyword","value":"Reforma"},"provenance":null},{"subject":{"scheme":"keyword","value":"Biblia"},"provenance":null},{"subject":{"scheme":"keyword","value":"Reformation"},"provenance":null},{"subject":{"scheme":"FOS","value":"06 humanities and the arts"},"provenance":null},{"subject":{"scheme":"FOS","value":"0603 philosophy, ethics and religion"},"provenance":null}],"mainTitle":"La «Biblia filosófica» y la Reforma: el caso de John Locke","subTitle":null,"descriptions":["La transición de la Escritura como una obra sobrenatural a un mero texto es algo que tiene que ver con el movimiento reformado, sin embargo, no se puede atribuir como tal a la Reforma, sino sobre todo a la corriente filosófica ilustrada, nutrida de las convicciones que movilizó la Reforma. El artículo analiza esta corriente en uno de sus predecesores: John Locke. Su obra contribuyó a generar la «Biblia académica», como contrapuesta a la «Biblia escriturística». En la obra de Locke se pone de manifiesto una dialéctica entre el carácter sobrenatural de la Escritura y la consideración de la razón como revelación natural, que la conduce a numerosas aporías. De ahí que la bibliografía haya considerado a John Locke alternativamente calvinista, latitudinario, arminiano, sociniano o unitariano. El artículo presenta estas aporías y procura una evaluación de su aportación a la cuestión de la interpretación bíblica, que es indisociable de su fe, de su epistemología y de su teoría del lenguaje."],"publicationDate":"2018-01-01","publisher":"Consejo Superior de Investigaciones Científicas (CSIC)","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::00a9b2299bf931ddb343018aedbf8131","originalIds":["50|00064aabbda9::00a9b2299bf931ddb343018aedbf8131","oai:navarra.escire.net:10171/59140"],"pids":[{"scheme":"handle","value":"10171/59140"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.3384854E-9,"popularity":9.41487E-10,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/59140"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/59140"],"publicationDate":"2018-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Morell-Azanza, L. (Lydia)","name":"L.","surname":"Morell-Azanza","rank":1,"pid":null},{"id":null,"fullName":"Ojeda-Rodríguez, A. (Ana)","name":"A.","surname":"Ojeda-Rodríguez","rank":2,"pid":null},{"id":null,"fullName":"Ochotorena-Elicegui, A. (Amaia)","name":"A.","surname":"Ochotorena-Elicegui","rank":3,"pid":null},{"id":null,"fullName":"Martin-Calvo, N. (Nerea)","name":"N.","surname":"Martin-Calvo","rank":4,"pid":null},{"id":null,"fullName":"Chueca, M. (María)","name":"M.","surname":"Chueca","rank":5,"pid":null},{"id":null,"fullName":"Marti-del-Moral, A. (Amelia)","name":"A.","surname":"Marti-Del-Moral","rank":6,"pid":null},{"id":null,"fullName":"Azcona-San-Julian, M.C. (María Cristina)","name":"M. C.","surname":"Azcona-San-Julian","rank":7,"pid":null}],"openAccessColor":null,"publiclyFunded":null,"eoscIfGuidelines":null,"type":"other","language":{"code":"eng","label":"English"},"countries":null,"subjects":[{"subject":{"scheme":"keyword","value":"Accelerometer"},"provenance":null},{"subject":{"scheme":"keyword","value":"Leptin"},"provenance":null},{"subject":{"scheme":"keyword","value":"MVPA"},"provenance":null},{"subject":{"scheme":"keyword","value":"Materias Investigacion::Ciencias de la Salud::Nutrición y dietética"},"provenance":null},{"subject":{"scheme":"keyword","value":"Obesity children"},"provenance":null},{"subject":{"scheme":"keyword","value":"Metabolic risk"},"provenance":null},{"subject":{"scheme":"FOS","value":"03 medical and health sciences"},"provenance":null},{"subject":{"scheme":"FOS","value":"0302 clinical medicine"},"provenance":null}],"mainTitle":"Changes in objectively measured physical activity after a multidisciplinary lifestyle intervention in children with abdominal obesity: a randomized control trial","subTitle":null,"descriptions":["Background: Physical activity (PA) is associated with changes in body composition that affect insulin sensitivity and leptin levels. Few studies have assessed the effect of lifestyle interventions on changes in objectively measured PA levels in obese children. To evaluate the effects of a multidisciplinary lifestyle intervention on anthropometric indices, biochemical parameters and accelerometer measured PA in abdominal obese children. Methods: A randomized control trial was performed in 106 children and adolescents with abdominal obesity. Participants were randomly assigned to usual or intensive care group for 8-week. PA was measured by accelerometry over four days including, at least, two weekdays in all participants. Both groups were encouraged to accumulate an extra time of 200 min per week in their PA. Results: At baseline, 75% of subjects do not fulfill the WHO recommendation of being more than 60 min/day on moderate-to-vigorous PA (MVPA). The intensive care group achieved a significant reduction in anthropometric indexes compared to the usual care but no significant change was found in biochemical or PA parameters. Both groups achieved a significant reduction in light PA. Interestingly, intensive care participants significantly increased MVPA in 5.5 min/day. Moreover, an inverse association between changes in MVPA and leptin levels was found. Conclusion: The two lifestyle intervention reduced anthropometric indexes and lowered light PA in abdominal obese children. No significant differences were observed between intensive care and usual care in regard to PA. Intensive care participants significantly increase physical activity (MVPA) and, changes in MVPA were inversely associated with changes in leptin levels after the intervention."],"publicationDate":"2019-01-01","publisher":"Springer Science and Business Media LLC","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::00ad0f93d4738639fcdbc7a4297a8297","originalIds":["oai:navarra.escire.net:10171/61974","50|00064aabbda9::00ad0f93d4738639fcdbc7a4297a8297"],"pids":[{"scheme":"handle","value":"10171/61974"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.3384854E-9,"popularity":1.0708374E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/61974"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/61974"],"publicationDate":"2019-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Garmendia, I. (Irati)","name":"I.","surname":"Garmendia","rank":1,"pid":null},{"id":null,"fullName":"Pajares, M.J. (María José)","name":"M. J.","surname":"Pajares","rank":2,"pid":null},{"id":null,"fullName":"Hermida-Prado, F. (Francisco)","name":"F.","surname":"Hermida-Prado","rank":3,"pid":null},{"id":null,"fullName":"Ajona, D. (Daniel)","name":"D.","surname":"Ajona","rank":4,"pid":null},{"id":null,"fullName":"Bertolo, C. (Cristina)","name":"C.","surname":"Bertolo","rank":5,"pid":null},{"id":null,"fullName":"Lavín, A. (Amaya)","name":"A.","surname":"Lavín","rank":6,"pid":null},{"id":null,"fullName":"Remirez, A. (Ana)","name":"A.","surname":"Remirez","rank":7,"pid":null},{"id":null,"fullName":"Valencia, K. (Karmele)","name":"K.","surname":"Valencia","rank":8,"pid":null},{"id":null,"fullName":"Moreno, H. (Haritz)","name":"H.","surname":"Moreno","rank":9,"pid":null},{"id":null,"fullName":"Ferrer, I. (Irene)","name":"I.","surname":"Ferrer","rank":10,"pid":null},{"id":null,"fullName":"Behrens, C. (C.)","name":"C.","surname":"Behrens","rank":11,"pid":null},{"id":null,"fullName":"Cuadrado, M. (Myriam)","name":"M.","surname":"Cuadrado","rank":12,"pid":null},{"id":null,"fullName":"Paz-Ares, L. (Luis)","name":"L.","surname":"Paz-Ares","rank":13,"pid":null},{"id":null,"fullName":"Bustelo, X.R. (Xose R.)","name":"X. R.","surname":"Bustelo","rank":14,"pid":null},{"id":null,"fullName":"Gil-Bazo, I. (Ignacio)","name":"I.","surname":"Gil-Bazo","rank":15,"pid":null},{"id":null,"fullName":"Alameda, D. (Daniel)","name":"D.","surname":"Alameda","rank":16,"pid":null},{"id":null,"fullName":"Lecanda, F. (Fernando)","name":"F.","surname":"Lecanda","rank":17,"pid":null},{"id":null,"fullName":"Calvo-González, A. (Alfonso)","name":"A.","surname":"Calvo-González","rank":18,"pid":null},{"id":null,"fullName":"Felip, E. (Enriqueta)","name":"E.","surname":"Felip","rank":19,"pid":null},{"id":null,"fullName":"Sanchez-Cespedes, M. (Montserrat)","name":"M.","surname":"Sanchez-Cespedes","rank":20,"pid":null},{"id":null,"fullName":"Wistuba, I.I. (Ignacio I.)","name":"I. I.","surname":"Wistuba","rank":21,"pid":null},{"id":null,"fullName":"Granda-Díaz, R. (Rocío)","name":"R.","surname":"Granda-Díaz","rank":22,"pid":null},{"id":null,"fullName":"Rodrigo, J.P. (Juan P.)","name":"J. P.","surname":"Rodrigo","rank":23,"pid":null},{"id":null,"fullName":"García-Pedrero, J.M. (Juana M.)","name":"J. M.","surname":"García-Pedrero","rank":24,"pid":null},{"id":null,"fullName":"Pio, R. (Rubén)","name":"R.","surname":"Pio","rank":25,"pid":null},{"id":null,"fullName":"Montuenga-Badia, L.M. (Luis M.)","name":"L. M.","surname":"Montuenga-Badia","rank":26,"pid":null},{"id":null,"fullName":"Agorreta, J. (Jackeline)","name":"J.","surname":"Agorreta","rank":27,"pid":null}],"openAccessColor":null,"publiclyFunded":null,"eoscIfGuidelines":null,"type":"other","language":{"code":"eng","label":"English"},"countries":null,"subjects":[{"subject":{"scheme":"keyword","value":"Dasatinib"},"provenance":null},{"subject":{"scheme":"keyword","value":"YES1"},"provenance":null},{"subject":{"scheme":"keyword","value":"Redictive biomarker"},"provenance":null},{"subject":{"scheme":"keyword","value":"Src family kinases"},"provenance":null},{"subject":{"scheme":"keyword","value":"Lung cancer"},"provenance":null},{"subject":{"scheme":"FOS","value":"03 medical and health sciences"},"provenance":null},{"subject":{"scheme":"FOS","value":"0302 clinical medicine"},"provenance":null}],"mainTitle":"YES1 drives lung cancer growth and progression and predicts sensitivity to dasatinib","subTitle":null,"descriptions":["Rationale: The characterization of new genetic alterations is essential to assign effective personalized therapies in non–small cell lung cancer (NSCLC). Furthermore, finding stratification biomarkers is essential for successful personalized therapies. Molecular alterations of YES1, a member of the SRC (proto-oncogene tyrosine-protein kinase Src) family kinases (SFKs), can be found in a significant subset of patients with lung cancer. Objectives: To evaluate YES1 (v-YES-1 Yamaguchi sarcoma viral oncogene homolog 1) genetic alteration as a therapeutic target and predictive biomarker of response to dasatinib in NSCLC. Methods: Functional significance was evaluated by in vivo models of NSCLC and metastasis and patient-derived xenografts. The efficacy of pharmacological and genetic (CRISPR [clustered regularly interspaced short palindromic repeats]/Cas9 [CRISPR-associated protein 9]) YES1 abrogation was also evaluated. In vitro functional assays for signaling, survival, and invasion were also performed. The association between YES1 alterations and prognosis was evaluated in clinical samples. Measurements and Main Results: We demonstrated that YES1 is essential for NSCLC carcinogenesis. Furthermore, YES1 overexpression induced metastatic spread in preclinical in vivo models. YES1 genetic depletion by CRISPR/Cas9 technology significantly reduced tumor growth and metastasis. YES1 effects were mainly driven by mTOR (mammalian target of rapamycin) signaling. Interestingly, cell lines and patient-derived xenograft models with YES1 gene amplifications presented a high sensitivity to dasatinib, an SFK inhibitor, pointing out YES1 status as a stratification biomarker for dasatinib response. Moreover, high YES1 protein expression was an independent predictor for poor prognosis in patients with lung cancer. Conclusions: YES1 is a promising therapeutic target in lung cancer. Our results provide support for the clinical evaluation of dasatinib treatment in a selected subset of patients using YES1 status as predictive biomarker for therapy."],"publicationDate":"2019-01-01","publisher":"American Thoracic Society","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::00ad26bbd63dbbca40779927fbc0a4d7","originalIds":["50|00064aabbda9::00ad26bbd63dbbca40779927fbc0a4d7","oai:navarra.escire.net:10171/63276"],"pids":[{"scheme":"handle","value":"10171/63276"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.3384854E-9,"popularity":1.0708374E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":[{"code":"cancer-research","label":"Cancer Research","provenance":null}],"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/63276"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/63276"],"publicationDate":"2019-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null}]}